Catalytical promiscuity of α-amylase: synthesis of 3-substituted 2H-chromene derivatives via biocatalytic domino oxa-Michael/aldol condensations

LH Zhou, N Wang, W Zhang, ZB Xie, XQ Yu

Index: Zhou, Long-Hua; Wang, Na; Zhang, Wei; Xie, Zong-Bo; Yu, Xiao-Qi Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 91, p. 37 - 43

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Citation Number: 11

Abstract

Abstract An facile and green one-pot route has been developed for the synthesis of chromenes using salicylaldehyde and α, β-unsaturated ketones. α-Amylase from Bacillus subtilis shows excellent catalytic activity and exerts good adaptability to different substrates in the reaction. This promiscuous enzyme-catalyzed domino reaction not only extends the application of α-amylase from B. subtilis for new chemical transformations, but also ...

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