Chromene??Based Synthetic Chalcones as Potent Antileishmanial Agents: Synthesis and Biological Activity

…, S Heydari, SK Ardestani, F Poorrajab…

Index: Foroumadi, Alireza; Emami, Saeed; Sorkhi, Maedeh; Nakhjiri, Maryam; Nazarian, Zohreh; Heydari, Samaneh; Ardestani, Sussan K.; Poorrajab, Fatemeh; Shafiee, Abbas Chemical Biology and Drug Design, 2010 , vol. 75, # 6 p. 590 - 596

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Citation Number: 23

Abstract

Two types of regioisomeric chromene-based chalcones namely, 1-(6-methoxy-2H-chromen- 3-yl)-3-phenylpropen-1-ones and 3-(6-methoxy-2H-chromen-3-yl)-1-phenylpropen-1-ones were prepared and investigated for their antileishmanial activity against promastigotes form of Leishmania major. The obtained results from in vitro biological assays indicated that chloro-substituted 1-(6-methoxy-2H-chromen-3-yl)-3-phenylpropen-1-ones exhibited ...

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