Tetrahedron

Engineering tethered DNA molecules by the convertible nucleoside approach

AM Macmillan, GL Verdine

Index: MacMillan, Andrew M.; Verdine, Gregory L. Tetrahedron, 1991 , vol. 47, # 14/15 p. 2603 - 2616

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Citation Number: 110

Abstract

Non-natural functional groups, tethered to DNA, provide a chemical handle for the site- specific attachment of reporter and effector elements. Herein we report a general strategy for the synthesis of oligodeoxynucleotides bearing tethered functionality (functionally tethered oligonucleotides, FTOs). In this approach, the convertible nucleoside 4-O-(2, 4, 6- trimethylphenyl)-2′-deoxyuridine (TMP-dU) is introduced site-specifically into DNA ...

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