Synthesis and cytostatic evaluation of 4-N-alkanoyl and 4-N-alkyl gemcitabine analogues

J Pulido, AJ Sobczak, J Balzarini…

Index: Kraszewski; Delort; Teoule Tetrahedron Letters, 1986 , vol. 27, # 7 p. 861 - 864

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Citation Number: 6

Abstract

... Volume: Page: ... and its cellular uptake is primarily facilitated by human equilibrative nucleoside transport protein 1 (hENT1).(7) Gemcitabine is ... 4-amino group targeting extracellular DNA has been reported with low toxicity but high tumor efficacy.(27) In addition ...

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Engineering tethered DNA molecules by the convertible nucleo...

[MacMillan, Andrew M.; Verdine, Gregory L. Tetrahedron, 1991 , vol. 47, # 14/15 p. 2603 - 2616]

Transformations of thiopyrimidine and thiopurine nucleosides...

[Saladino, Raffaele; Mincione, Enrico; Crestini, Claudia; Mezzetti, Maurizio Tetrahedron, 1996 , vol. 52, # 19 p. 6759 - 6780]

Engineering tethered DNA molecules by the convertible nucleo...

[MacMillan, Andrew M.; Verdine, Gregory L. Tetrahedron, 1991 , vol. 47, # 14/15 p. 2603 - 2616]

Convenient intermediates for the preparation of C-4 modified...

[Miah, Anwar; Reese, Colin B.; Song, Quanlai Nucleosides and Nucleotides, 1997 , vol. 16, # 1-2 p. 53 - 65]