Mesitylmagnesium Bromide as a Reagent in the Acetoacetic Ester Condensation1

MA Spielman, MT Schmidt

Index: Spielman; Schmidt Journal of the American Chemical Society, 1937 , vol. 59, p. 2010

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Citation Number: 7

Abstract

An investigation recently completed in this Laboratory2 has revealed that neither ethyl isovalerate nor ethyl t-butylacetate undergoes the acetoacetic ester condensation in the presence of sodium ethoxide, either under equilibrium conditions or when provision is made for removal of alcohol from the reaction mixture. Both of these esters contain an a-methylene group, but their non-reactivity places them in a category with ethyl isobutyrate, which is ...