Abstract The reaction of lithium on α, α-dichloroesters and α, α-disubstituted α- monohaloesters in THF at 0 to− 5 C leads to the formation of the lithioanalogs of the corresponding Reformatsky reagents in good yields (80–90%). Their reactivity has been tested toward various electrophiles. It illustrates the wide scope of synthetic utility of these reagents (alkylation with primary and secondary alkyl bromides, hydroxy alkylation, ...
