Exploring the potential of 3′-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin

…, J Debnath, P Dutta, BK Sahoo, S Dasgupta

Index: Ghosh, Kalyan S.; Debnath, Joy; Dutta, Palash; Sahoo, Bijaya K.; Dasgupta, Swagata Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 2819 - 2828

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Citation Number: 7

Abstract

In this study, compounds with a carboxy ester in lieu of the phosphate ester at the 3′- position have been employed to inhibit the ribonucleolytic activity of ribonuclease A (RNase A). Phosphates at the 3′-position of pyrimidine bases are well-known inhibitors of the protein. We have investigated the inhibition of RNase A by 3′-O-carboxy esters of thymidine. The compounds behave as competitive inhibitors with inhibition constants ...