Efficient synthesis of nucleoside diphosphate glycopyranoses

S Wendicke, S Warnecke…

Index: Wendicke, Silke; Warnecke, Svenja; Meier, Chris Angewandte Chemie - International Edition, 2008 , vol. 47, # 8 p. 1500 - 1502

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Citation Number: 53

Abstract

Nucleoside diphosphate pyranoses 1 (NDP sugars; see Scheme 1) play a key role as glycosyl donors in the synthesis of oligo-and polysaccharides.[1, 2] Moreover, they serve as precursors of deoxysugars, aminodeoxysugars, chainbranched sugars, uronic acids, as well as glycoconjugates. In biosynthetic pathways the energy-rich linkage between the C1 atom and the β-phosphate is cleaved, and thus the glycosyl part is enzymatically transferred to ...