Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions

TN Glasnov, JD Holbrey, CO Kappe, KR Seddon…

Index: Glasnov, Toma N.; Kappe, C. Oliver; Holbrey, John D.; Seddon, Kenneth R.; Yan, Ting Green Chemistry, 2012 , vol. 14, # 11 p. 3071 - 3076,6

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Citation Number: 16

Abstract

The ionic liquid, tributylmethylammonium methylcarbonate, has been employed as a catalytic base for clean N-methylation of indole with dimethylcarbonate. The reaction conditions were optimised under microwave heating to give 100% conversion and 100% selectivity to N-methylindole, and subsequently transferred to a high temperature/high pressure (285° C/150 bar) continuous flow process using a short (3 min) residence time ...

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