Formation and reactions of N 7-aminoguanosine and derivatives

…, RG Mundkowski, M Voehler, FF Kadlubar

Index: Guengerich, F. Peter; Mundkowski, Ralf G.; Voehler, Markus; Kadlubar, Fred F. Chemical Research in Toxicology, 1999 , vol. 12, # 10 p. 906 - 916

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Citation Number: 36

Abstract

Arylamines are mutagens and carcinogens and are thought to initiate tumors by forming adducts with DNA. The major adducts are C 8-guanyl, and we have previously suggested a role for guanyl-N 7 intermediates in the formation process. N 7-Aminoguanosine (Guo) was synthesized and characterized, with the position of the NH2 at N7 established by two- dimensional rotating frame Overhauser enhancement NMR spectroscopy. In DMF, N 7- ...