Synthetic communications

New Approach for the Synthesis of N??Indolyl Ketones and Aldehydes

HS Ding, CH Yang, YY Xie

Index: Ding, Hua-Sheng; Yang, Chun-Hao; Xie, Yu-Yuan Synthetic Communications, 2005 , vol. 35, # 20 p. 2625 - 2632

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Abstract

In our recent studies of anticancer agents, we have found some interesting indole α??methylene?螃摸?butyrolactone compounds, prepared from the intermediates indolyl aldehydes or ketones (such as compound 1), which can significantly inhibit AKT??mTOR signaling pathway kinases. Furthermore, the indole ring system found in a wide range of naturally occurring compounds has attracted great interest for its biological activities.11. Kawashima , Y. , Amanuma , F. , ...