Synthetic communications

New Approach for the Synthesis of N??Indolyl Ketones and Aldehydes

HS Ding, CH Yang, YY Xie

文献索引：Ding, Hua-Sheng; Yang, Chun-Hao; Xie, Yu-Yuan Synthetic Communications, 2005 , vol. 35, # 20 p. 2625 - 2632

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摘要

In our recent studies of anticancer agents, we have found some interesting indole α??methylene?螃摸?butyrolactone compounds, prepared from the intermediates indolyl aldehydes or ketones (such as compound 1), which can significantly inhibit AKT??mTOR signaling pathway kinases. Furthermore, the indole ring system found in a wide range of naturally occurring compounds has attracted great interest for its biological activities.11. Kawashima , Y. , Amanuma , F. , ...