Synthesis and evaluation of new 6-hydroximinosteroid analogs as cytotoxic agents

J Poza, M Rega, V Paz, B Alonso, J Rodríguez…

Index: Poza, Javier; Rega, Miriam; Paz, Vanessa; Alonso, Beatriz; Rodriguez, Jaime; Salvador, Nelida; Fernandez, Antonio; Jimenez, Carlos Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4722 - 4740

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Citation Number: 45

Abstract

Taking into account the structural requirements for cytotoxicity, several new hydroximinosteroid derivatives have been prepared and evaluated for their cytotoxic activity against A-549, H116, PSN1, and T98G cultured tumor cell lines in order to obtain further information on the potential pharmacophoric core of this type of compound. The influence of the oxygenated position in the A ring, the presence of an additional oxygenated position at ...