Synthesis

Reductive One Batch Synthesis of N-Substituted Pyrrolidines from Primary Amines and 2, 5-Dimethoxytetrahydrofuran

G Verardo, A Dolce, N Toniutti

Index: Verardo, Giancarlo; Dolce, Anna; Toniutti, Nicoletta Synthesis, 1999 , # 1 p. 74 - 79

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Citation Number: 10

Abstract

Abstract: The construction of the pyrrolidine ring about a nitrogen of a primary amine by a reductive condensation reaction using 2, 5-dimethoxytetrahydrofuran and sodium borohydride in acidic water medium is described. The reaction is fast, affords good to excellent yields and appears insensitive to electron effects and severe steric hindrance; it is found to be compatible with a large variety of aryl substituents, including nitro and oxo ...

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