e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synlett

A convenient procedure for parallel ester hydrolysis

MO Anderson, J Moser, J Sherrill, RK Guy

Index: Anderson, Marc O.; Moser, Jamie; Sherrill, John; Guy, R. Kiplin Synlett, 2004 , # 13 p. 2391 - 2393

Full Text: HTML

Citation Number: 12

Abstract

Abstract The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.

4-Aminobenzotrifluoride Structure

4-Aminobenzotri...

~%

9-chloro-6-methoxy-2-(trifluoromethyl)acridine Structure

9-chloro-6-meth...

ethyl cinnamate Structure

ethyl cinnamate

~99%

Cinnamic acid Structure

Ethyl salicylate Structure

Ethyl salicylate

~84%

Salicylic acid Structure

Methyl 4-fluoro-2-hydroxybenzoate Structure

Methyl 4-fluoro...

~99%

4-Fluoro-2-hydroxybenzoic acid Structure

4-Fluoro-2-hydr...

methyl 4-chloro-2-(4-methoxyphenyl)aminobenzoate Structure

methyl 4-chloro...

~%

Benzoic acid,4-chloro-2-[(4-methoxyphenyl)amino]- Structure

Benzoic acid,4-...

p-Anisidine Structure

~%

Benzoic acid,4-chloro-2-[(4-methoxyphenyl)amino]- Structure

Benzoic acid,4-...

methyl 4-chloro-2-(trifluoromethylsulfonyloxy)benzoate Structure

methyl 4-chloro...

~%

Benzoic acid,4-chloro-2-[(4-methoxyphenyl)amino]- Structure

Benzoic acid,4-...

methyl 4-(4-methoxyphenyl)-4-oxo-butanoate Structure

methyl 4-(4-met...

~85%

4-(4-Methoxyphenyl)-4-oxobutanoic acid Structure

4-(4-Methoxyphe...

Parallel synthesis of 9-aminoacridines and their evaluation ...

[Anderson, Marc O.; Sherrill, John; Madrid, Peter B.; Liou, Ally P.; Weisman, Jennifer L.; DeRisi, Joseph L.; Guy, R. Kiplin Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 2 p. 334 - 343]

Parallel synthesis of 9-aminoacridines and their evaluation ...

[Anderson, Marc O.; Sherrill, John; Madrid, Peter B.; Liou, Ally P.; Weisman, Jennifer L.; DeRisi, Joseph L.; Guy, R. Kiplin Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 2 p. 334 - 343]

Parallel synthesis of 9-aminoacridines and their evaluation ...

[Anderson, Marc O.; Sherrill, John; Madrid, Peter B.; Liou, Ally P.; Weisman, Jennifer L.; DeRisi, Joseph L.; Guy, R. Kiplin Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 2 p. 334 - 343]