Journal of medicinal chemistry

Trypanocidal 1, 3-arylene diketone bis (guanylhydrazones). Structure-activity relationships among substituted and heterocyclic analogs

P Ulrich, A Cerami

Index: Ulrich, Peter; Cerami, Anthony Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 35 - 40

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Citation Number: 38

Abstract

114-116. chloride, an antitumor agent that formally resembles 1 and 2 in having two terminal amidine moieties, has been shown to possess modest trypanosuppressive proper tie^.^ It occurred to us that simple aromatic analogues of 3 might be better trypanocides, based on the aromatic character of 1 and 2 and of other classes of cationic trypanocides, such as quinapyramine. This conjecture proved to be correct. In our preliminary study of aromatic ...

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Deactivation of triplet phenyl alkyl ketones by conjugativel...

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