Efficient amide formation from arylamines and esters promoted by AlCl3/Et3N: an experimental and computational investigation

X Tong, Z Ren, X Qü, Q Yang, W Zhang

Index: Tong, Xinli; Ren, Zhangshun; Que, Xiaolong; Yang, Qiwu; Zhang, Wenqin Research on Chemical Intermediates, 2012 , vol. 38, # 8 p. 1961 - 1968

Full Text: HTML

Citation Number: 2

Abstract

Abstract Efficient and selective preparation of amides from arylamines and esters has been achieved with an AlCl 3/Et 3 N pair under mild conditions. A large number of arylamines were successfully acylated to the corresponding amides in high yields and short reaction times. For instance, a 94% yield of p-bromoacetanilide was obtained from p-bromoaniline and ethyl acetate in 10 min at room temperature. In addition, a computational study on the ...