Tetrahedron

Copper (I) halide catalysed synthesis of alkyl aryl and alkyl heteroaryl ethers

MA Keegstra, THA Peters, L Brandsma

Index: Keegstra, Menno A.; Peters, Theo H. A.; Brandsma, Lambert Tetrahedron, 1992 , vol. 48, # 17 p. 3633 - 3652

Full Text: HTML

Citation Number: 114

Abstract

A number of alkyl aryl and alkyl heteroaryl ethers have been prepared from (hetero) aryl halides (mainly bromides) and sodium alkoxides, using copper (I) bromide as a catalyst. The influence of the main solvent, the halogen atom, reaction temperature and the presence of oxygen upon the rate and selectivity has been studied. Furthermore the decomposition of the catalyst and the reduction of the aryl halide are studied.