The Journal of organic chemistry

Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl-and ferrocenyldialkylphosphine ligands

NA Beare, JF Hartwig

Index: Beare, Neil A.; Hartwig, John F. Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 541 - 555

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Citation Number: 194

Abstract

Palladium-catalyzed reactions of aryl bromides and chlorides with two common stabilized carbanions enolates of dialkyl malonates and alkyl cyanoesters are reported. An exploration of the scope of these reactions was conducted, and the processes were shown to occur in a general fashion. Using P (t-Bu) 3 (1), the pentaphenylferrocenyl ligand (Ph5C5) Fe (C5H4) P (t-Bu) 2 (2), or the adamantyl ligand (1-Ad) P (t-Bu) 2 (3), reactions of electron-poor and ...