Studies on bi-heterocyclic compounds. I. 6-Substituted dihydro-1, 4-thiazinones.

H YAMAZAKI, H HARADA, K MATSUZAKI…

Index: Yamazaki; Harada; Matsuzaki; et al. Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 6 p. 2243 - 2253

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Citation Number: 4

Abstract

Reactions of 5-methyl-2H-1, 4-thiazin-3 (4H)-one (4) with various N-acylpyridinium salts (7a- g) led to (N-acyldihydropyridyl) thiazinones (5a-g), oxidation of which yielded a new class of pyridylthiazinones (6a-g). These reactions were applied to the synthesis of other azaarylthiazinones. Some of these azaarylthiazinones, particularly 6-(4-pyridyl) thiazinones (6a, 14a and 14b) showed positive inotropic activity with little chronotropic effect on ...