N2, N2′??disubstituted oxalic acid bishydrazides: novel ligands for copper??catalyzed C N coupling reactions in water

F Meng, C Wang, J Xie, X Zhu…

Index: Meng, Fei; Wang, Chenxia; Xie, Jianwei; Zhu, Xinhai; Wan, Yiqian Applied Organometallic Chemistry, 2011 , vol. 25, # 5 p. 341 - 347

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Citation Number: 10

Abstract

Abstract A series of N 2, N 2′-disubstituted oxalic acid bishydrazides were synthesized. Some, for example, N 2, N 2′-di-1-(4-methoxyphenyl)-ethanyloxylic-(bishydrazide), are novel and effective ligands for copper-catalyzed Ullmann-type C [BOND] N coupling reaction in water. A variety of amines could be effectively N-arylated with aryl halides under both microwave irradiation and conventional heating (even at 30 C) with good to excellent ...