Structure–activity relationship study of homoallylamines and related derivatives acting as antifungal agents

…, M Sortino, VV Kouznetsov, SA Zacchino…

Index: Suvire, Fernando D.; Sortino, Maximiliano; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana A.; Cruz, Uriel Mora; Enriz, Ricardo D. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1851 - 1862

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Citation Number: 34

Abstract

The synthesis, in vitro evaluation, and structure–activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl) amine and N-(4-chlorophenyl)-N-(2- furylmethyl) amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural ...