e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Journal of Medicinal Chemistry

Antituberculous Agents. II. 1 N, N'-Diisopropylethylenediamine and Analogs

RG Shepherd, RG Wilkinson

Index: Shepherd,R.G.; Wilkinson,R.G. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 823 - 835

Full Text: HTML

Citation Number: 40

Abstract

The preparation and antituberculous activity of sonie forty homologous alkylenediamines [(C, H2,+ 1NH) 2 (CH~) m] is given along with a discussion of the structural features required for high activity. N, N'-Diisopropylethylenediamine (I) and its secondary (IV) and tertiary (V) butyl analogs displayed in mice about one-half thr antituherculous activity of streptomycin.

1,2-Ethanediamine Structure

1,2-Ethanediamine

2-Butanone Structure

~%

N,N'-BIS-2-BUTYLETHYLENEDIAMINE Structure

N,N'-BIS-2-BUTY...

N-Isopropylethylenediamine Structure

N-Isopropylethy...

2-Butanone Structure

~%

N-2-BUTYL-N'-ISOPROPYLETHYLENEDIAMINE Structure

N-2-BUTYL-N'-IS...

Butyraldehyde Structure

1,2-Ethanediamine Structure

1,2-Ethanediamine

~%

N,N'-Dibutyl-1,2-ethanediamine Structure

N,N'-Dibutyl-1,...

1,2-Ethanediamine Structure

1,2-Ethanediamine

Isobutyraldehyde Structure

Isobutyraldehyde

~%

N,N'-bis(2-methylpropyl)ethane-1,2-diamine Structure

N,N'-bis(2-meth...

2-Heptanone Structure

1,2-Ethanediamine Structure

1,2-Ethanediamine

~%

N,N'-di(heptan-2-yl)ethane-1,2-diamine Structure

N,N'-di(heptan-...

tert-amylamine Structure

1,2-Dibromoethane Structure

1,2-Dibromoethane

~%

N,N'-Bis(2-methyl-2-butanyl)-1,2-ethanediamine Structure

N,N'-Bis(2-meth...

N-(2-chloroethyl)propan-2-amine Structure

N-(2-chloroethy...

Structure

~%

N-phenyl-N'-propan-2-ylethane-1,2-diamine Structure

N-phenyl-N'-pro...

1,2-Diaminopropane Structure

1,2-Diaminopropane

Acetone Structure

~%

1-N,2-N-di(propan-2-yl)propane-1,2-diamine Structure

1-N,2-N-di(prop...

1,2-Ethanediamine Structure

1,2-Ethanediamine

4-Methyl-2-pentanone Structure

4-Methyl-2-pentanone

~%

N,N'-bis(4-methylpentan-2-yl)ethane-1,2-diamine Structure

N,N'-bis(4-meth...

N-(2-chloroethyl)propan-2-amine Structure

N-(2-chloroethy...

Dibutylamine Structure

~%

N',N'-dibutyl-N,N-dimethylethane-1,2-diamine Structure

N',N'-dibutyl-N...

(2-chloro-ethyl)-isopropyl-methyl-amine, hydrochloride Structure

(2-chloro-ethyl...

isopropylamine Structure

~%

N'-methyl-N,N'-di(propan-2-yl)ethane-1,2-diamine Structure

N'-methyl-N,N'-...

N,N'-Diisopropylethylenediamine Structure

N,N'-Diisopropy...

Ethanoic anhydride Structure

Ethanoic anhydride

~%

N-[2-[acetyl(propan-2-yl)amino]ethyl]-N-propan-2-ylacetamide Structure

N-[2-[acetyl(pr...

1-Dodecanamine,N-methyl- Structure

1-Dodecanamine,...

(2-Chloroethyl)dimethylamine hydrochloride Structure

(2-Chloroethyl)...

~%

N'-dodecyl-N,N,N'-trimethylethane-1,2-diamine Structure

N'-dodecyl-N,N,...

1,2-Ethanediamine Structure

1,2-Ethanediamine

Acetone Structure

~%

N,N,N'-triisopropylethylenediamine Structure

N,N,N'-triisopr...

Pentan-2-one Structure

1,2-Ethanediamine Structure

1,2-Ethanediamine

~%

N,N'-di(pentan-2-yl)ethane-1,2-diamine Structure

N,N'-di(pentan-...