butan-2-one

butan-2-one Structure
butan-2-one
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Common Name butan-2-one
CAS Number 78-93-3 Molecular Weight 72.106
Density 0.8±0.1 g/cm3 Boiling Point 75.6±3.0 °C at 760 mmHg
Molecular Formula C4H8O Melting Point -87 °C
MSDSbutan-2-one MSDS|SDS|pdf download Chinese USA Flash Point -3.3±0.0 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

Controlled Substances:Psychoactive Drugs/Narcotic Drugs/Hypertoxic Chemicals/Non-Medical Use of Narcotic Drugs and Psychotropic Substances


 Names

[ Name ]: butan-2-one
[ Synonym ]: More Synonyms

 Chemical & Physical Properties

[ Density ]: 0.8±0.1 g/cm3
[ Boiling Point ]: 75.6±3.0 °C at 760 mmHg
[ Melting Point ]: -87 °C
[ Molecular Formula ]: C4H8O
[ Molecular Weight ]: 72.106
[ Flash Point ]: -3.3±0.0 °C
[ Exact Mass ]: 72.057518
[ PSA ]: 17.07000
[ LogP ]: 0.37
[ Vapour density ]: 2.49 (vs air)
[ Vapour Pressure ]: 114.5±0.1 mmHg at 25°C
[ Index of Refraction ]: 1.367
[ Storage condition ]: 2-8°C
[ Water Solubility ]: 290 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EL6475000
CHEMICAL NAME :
2-Butanone
CAS REGISTRY NUMBER :
78-93-3
LAST UPDATED :
199712
DATA ITEMS CITED :
64
MOLECULAR FORMULA :
C4-H8-O
MOLECULAR WEIGHT :
72.12
WISWESSER LINE NOTATION :
2V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Human
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
100 ppm/5M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2737 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23500 mg/m3/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
607 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 gm/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
616 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
38 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5000 ppm/6H/90D-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - urine volume increased Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
750 ppm/7H/7D-I
TOXIC EFFECTS :
Liver - liver function tests impaired
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
55500 mg/kg/37W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
3000 ppm/7H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Specific Developmental Abnormalities - homeostasis
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1000 ppm/7H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
3000 ppm/7H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,339,1985 *** REVIEWS *** ACGIH TLV-STEL 885 mg/m3 (300 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 590 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW ECIET* European Chemical Industry Ecology and Toxicology Centre. Joint Assessment of Commodity Chemicals. (Avenue Louise 250, B-63, B-1050 Brussels, Belgium) Volume(issue)/page/year: (3),-,1983 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: DE89-563 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 200 ppm (590 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,29,1971 OSHA PEL (Gen Indu):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 150 ppm (445 mg/m3);STEL 300 ppm (890 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-BELGIUM:TWA 200 ppm (590 mg/m3);STEL 300 ppm (885 mg/m3) JAN 1993 OEL-DENMARK:TWA 100 ppm (290 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 150 ppm (440 mg/m3);STEL 190 ppm;Skin JAN 1993 OEL-FRANCE:TWA 200 ppm (600 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-HUNGARY:TWA 200 mg/m3;STEL 600 mg/m3 JAN 1993 OEL-INDIA:TWA 200 ppm (590 mg/m3);STEL 300 ppm (885 mg/m3) JAN 1993 OEL-JAPAN:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-POLAND:TWA 200 mg/m3 JAN 1993 OEL-RUSSIA:TWA 200 ppm;STEL 200 mg/m3 JAN 1993 OEL-SWEDEN:TWA 50 ppm (150 mg/m3);STEL 100 ppm (300 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (590 mg/m3);STEL 400 ppmJAN 1993 OEL-TURKEY:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 200 ppm (590 mg/m3);STEL 300 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL ETHYL KETONE-air:10H TWA 200 ppm;STEL 300 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 13980 No. of Facilities: 64013 (estimated) No. of Industries: 319 No. of Occupations: 177 No. of Employees: 801382 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 13980 No. of Facilities: 87227 (estimated) No. of Industries: 318 No. of Occupations: 208 No. of Employees: 1447456 (estimated) No. of Female Employees: 245372 (estimated)

 Safety Information

[ Symbol ]: GHS02 GHS07
GHS02, GHS07
[ Signal Word ]: Danger
[ Hazard Statements ]: H225-H319-H336
[ Supplemental HS ]: Repeated exposure may cause skin dryness or cracking.
[ Precautionary Statements ]: P210-P305 + P351 + P338-P370 + P378-P403 + P235
[ Personal Protective Equipment ]: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]: F,Xi,T
[ Risk Phrases ]: R11:Highly Flammable. R36:Irritating to the eyes. R66:Repeated exposure may cause skin dryness or cracking. R67:Vapors may cause drowsiness and dizziness. R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with s
[ Safety Phrases ]: S9-S16-S45-S36/37
[ RIDADR ]: UN 1193 3/PG 2
[ WGK Germany ]: 1
[ RTECS ]: EL6475000
[ Packaging Group ]: II
[ Hazard Class ]: 3
[ HS Code ]: 2914120000

 Customs

[ HS Code ]: 2914120000
[ Summary ]: 2914120000 butan-2-one。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:5.5%。general tariff:30.0%

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