Tetrahedron Letters

Microwaves-assisted solvent-free synthesis of N-acetamides by amidation or aminolysis

C Ferroud, M Godart, S Ung, H Borderies, A Guy

Index: Ferroud, Clotilde; Godart, Marie; Ung, Stephane; Borderies, Helene; Guy, Alain Tetrahedron Letters, 2008 , vol. 49, # 18 p. 3004 - 3008

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Citation Number: 42

Abstract

Due to its interest in organic synthesis, the preparation of amides from the corresponding amines is an important and well-known transformation. The most popular methods for the synthesis of carboxamides involve the conversion of carboxylic acid to a more reactive functional group or an in situ activation by using coupling reagents. 2 Although good results are obtained with both approaches, they need often expensive coupling reagents, which lead to the formation of ...