e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron

Researches on antiviral agents. 4. Studies on the chemistry of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2, 4-di-O-acyloxypyrimidine derivatives as new acylation …

M Botta, R Saladino, G Gentile, V Summa, R Nicoletti…

Index: Botta; Saladino; Gentile; Summa; Nicoletti; Verri; Focher; Spadari Tetrahedron, 1994 , vol. 50, # 11 p. 3603 - 3618

Full Text: HTML

Citation Number: 13

Abstract

The synthesis of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2, 4-di-O-acyloxypyrimidine derivatives 2 and 5 along with their properties as acylating agents of amines, alcohols, thiols and α-amino acids have been reported. Interestingly some of the title products revealed an inhibitory activity against the human and herpetic DNA glycosylases.

n-butylamine Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~65%

6-Methyluracil Structure

Benzamide, N-butyl- Structure

Benzamide, N-butyl-

4-Aminophenol Structure

N/A Structure

~0%

2-Methoxy-6-methyl-4(1H)-pyrimidinone Structure

2-Methoxy-6-met...

N-(4-hydroxyphenyl)benzo[d][1,3]dioxole-5-carboxamide Structure

N-(4-hydroxyphe...

Cyclohexylamine Structure

Cyclohexylamine

N/A Structure

~0%

2-Methoxy-6-methyl-4(1H)-pyrimidinone Structure

2-Methoxy-6-met...

N/A Structure

2-Aminoethanol Structure

N/A Structure

~0%

2-Methoxy-6-methyl-4(1H)-pyrimidinone Structure

2-Methoxy-6-met...

N-(2-hydroxyethyl)benzo[d][1,3]dioxole-5-carboxamide Structure

N-(2-hydroxyeth...

N/A Structure

Structure

~0%

2-Methoxy-6-methyl-4(1H)-pyrimidinone Structure

2-Methoxy-6-met...

N-phenylbenzo[d][1,3]dioxole-5-carboxamide Structure

N-phenylbenzo[d...

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

Butanol Structure

~87%

6-Methyluracil Structure

n-Butyl benzoate Structure

n-Butyl benzoate

methyl DL-alaninate Structure

methyl DL-alaninate

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~90%

6-Methyluracil Structure

Bz-L-Ala-OMe Structure

2-Aminoethanol Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~99%

6-Methyluracil Structure

N-(2-hydroxyethyl)benzamide Structure

N-(2-hydroxyeth...

Diethylamine Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~91%

6-Methyluracil Structure

N,N-DIETHYLBENZAMIDE Structure

N,N-DIETHYLBENZAMIDE

4-Amino-1-butanol Structure

4-Amino-1-butanol

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~64%

6-Methyluracil Structure

N-(4-hydroxybutyl)benzamide Structure

N-(4-hydroxybut...

Ethanol Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~46%

6-Methyluracil Structure

Ethyl benzoate Structure

Thiophenol Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~81%

6-Methyluracil Structure

Benzoic acid, thio-, S-phenyl ester Structure

Benzoic acid, t...

N-Allylmethylamine Structure

N-Allylmethylamine

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

N-allyl-N-methylbenzamide Structure

N-allyl-N-methy...

methyl DL-alaninate Structure

methyl DL-alaninate

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

Bz-L-Ala-OMe Structure

L-VALINE METHYL ESTER Structure

L-VALINE METHYL...

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

(2S)-2-(benzoylamino)-3-methylbutyric acid methyl ester Structure

(2S)-2-(benzoyl...

Diethylamine Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

N,N-DIETHYLBENZAMIDE Structure

N,N-DIETHYLBENZAMIDE

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

Butanol Structure

~0%

6-Methyluracil Structure

n-Butyl benzoate Structure

n-Butyl benzoate

Thiophenol Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

Benzoic acid, thio-, S-phenyl ester Structure

Benzoic acid, t...

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

Benzyl alcohol Structure

~0%

6-Methyluracil Structure

benzyl benzoate Structure

benzyl benzoate

n-butylamine Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

Benzamide, N-butyl- Structure

Benzamide, N-butyl-

Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

Benzanilide Structure

6-Methyluracil Structure

Ethanol Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

Ethyl benzoate Structure

tert-Butyl glycinate Structure

tert-Butyl glycinate

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

hippuric acid tert-butyl ester Structure

hippuric acid t...

2-Aminoethanol Structure

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

N-(2-hydroxyethyl)benzamide Structure

N-(2-hydroxyeth...

4-Amino-1-butanol Structure

4-Amino-1-butanol

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

~0%

6-Methyluracil Structure

N-(4-hydroxybutyl)benzamide Structure

N-(4-hydroxybut...

6-methyl-2,4-pyrimidine-diyl dibenzoate Structure

6-methyl-2,4-py...

Benzyl alcohol Structure

~81%

6-Methyluracil Structure

benzyl benzoate Structure

benzyl benzoate

Solvent free, N, N′-carbonyldiimidazole (CDI) mediated amida...

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