6-Methyluracil

Modify Date: 2024-01-02 20:03:15

6-Methyluracil structure	Common Name	6-Methyluracil
	CAS Number	626-48-2	Molecular Weight	126.113
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₅H₆N₂O₂	Melting Point	318 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	208ºC
	Symbol	GHS08	Signal Word	Warning

Use of 6-Methyluracil

6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo[1][2].

Name	6-methyluracil
Synonym	More Synonyms

Description	6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo[1][2].
Related Catalog	Research Areas >> Metabolic Disease
In Vivo	6-Methyluracil (50 mg/kg; a single i.p.) produces a pronounced radioprotective effect in BALB and SHK mice[2].
References	[1]. Cromby CH, et, al. 6-Methyluracil excretion in 2-methylacetoacetyl-CoA thiolase deficiency and in two children with an unexplained recurrent ketoacidaemia. J Inherit Metab Dis. 1994;17(1):81-4. [2]. Taran IP, et, al. [The antiradiation action of 6-methyluracil]. Radiobiologiia. Mar-Apr 1993;33(2):285-90.

Density	1.2±0.1 g/cm3
Melting Point	318 °C (dec.)(lit.)
Molecular Formula	C₅H₆N₂O₂
Molecular Weight	126.113
Flash Point	208ºC
Exact Mass	126.042931
PSA	65.72000
LogP	-0.12
Index of Refraction	1.490
Water Solubility	7 g/L (22 ºC)

6-Methyluracil MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YR0700000

CHEMICAL NAME :: Uracil, 6-methyl-

CAS REGISTRY NUMBER :: 626-48-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H6-N2-O2

MOLECULAR WEIGHT :: 126.13

WISWESSER LINE NOTATION :: T6MVMVJ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 64500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 44,56,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 27,112,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 48,186,1985 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 8(10),49,1962 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 66,1382,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 20 mg/kg

SEX/DURATION :: female 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. Volume(issue)/page/year: 19,264,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1624 No. of Facilities: 89 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 293 (estimated) No. of Female Employees: 109 (estimated)

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H361
Precautionary Statements	P281
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R62;R63
Safety Phrases	S36/37/39-S45-S36/37
RIDADR	1759
WGK Germany	3
RTECS	YR0700000
Packaging Group	II
Hazard Class	8
HS Code	2942000000

Precursor 9
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DownStream 8
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HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.

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6-Methyluracil

2,4-Dihydroxy-6-methylpyrimidine

2,4(1H,3H)-Pyrimidinedione, 6-methyl-

6-Methylpyrimidin-2,4(1H,3H)-dion

EINECS 210-949-4

6-Methyl-2,4(1H,3H)-pyrimidinedione

6-Methylpyrimidine-2,4(1H,3H)-dione

6-methyl-1H-pyrimidine-2,4-dione

6-methylpyrimidine-2,4-diol

MFCD00006028

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China
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Dayang Chem (Hangzhou) Co., Ltd.
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6-Methyluracil

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