Tetrahedron Letters

Stereoselective synthesis of (S)-dapoxetine: a chiral auxiliary mediated approach

GL Khatik, R Sharma, V Kumar, M Chouhan, VA Nair

Index: Khatik, Gopal L.; Sharma, Ratnesh; Kumar, Varun; Chouhan, Mangilal; Nair, Vipin A. Tetrahedron Letters, 2013 , vol. 54, # 45 p. 5991 - 5993

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Citation Number: 7

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... An imidazolidin-2-one chiral auxiliary mediated acetate aldol reaction was explored in the enantioselective synthesis of (S)-dapoxetine (SSRI). The diastereoselective aldol adduct was transformed to highly enantiopure (S)-dapoxetine with overall good yield. ... Selective Serotonin Reuptake ...

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