Angiotensin-converting enzyme inhibitors. Perhydro-1, 4-thiazepin-5-one derivatives

H Yanagisawa, S Ishihara, A Ando…

Index: Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991

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Citation Number: 58

Abstract

Chemical Research Laboratory, Sankyo Co., Ltd., Hiromachi, Shinagawa-ku, Tokyo 140, Japan. Received April 13, 1987 c~-[6-[[(S)-l-(Ethoxycarbonyl)-3-phenylpropyl] amino]-5- oxoperhydro-l, 4-thiazepin-4-yl] acetic acids (monoester monoacids) and their dicarboxylic acids having the hydrophobic substituents at the 2-or 3-position of the thiazepinone ring were prepared and assayed for angiotensin-converting enzyme (ACE) inhibitory activity. ...