Two-enzyme coexpressed recombinant strain for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate

…, NI Ye, W Junchao, XU Zhihao, SUN Zhihao

Index: Su, Yuning; Ni, Ye; Wang, Junchao; Xu, Zhihao; Sun, Zhihao Chinese Journal of Catalysis, 2012 , vol. 33, # 9-10 p. 1650 - 1660

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Citation Number: 4

Abstract

(R)-2-Hydroxy-4-phenylbutyrate (HPBE) is an important chiral intermediate for the synthesis of angiotensin-converting enzyme (ACE) inhibitors. Asymmetric reduction of ethyl 2-oxo-4- phenyl-butyrate (OPBE) to (R)-HPBE using a recombinant strain can provide high enantioselectivity. Cofactor regeneration is a critical issue in the application of a recombinant strain. A carbonyl reductase gene (iolS) and a glucose dehydrogenase (GDH ...

~92%

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