Angiotensin-converting enzyme inhibitors. Perhydro-1, 4-thiazepin-5-one derivatives

H Yanagisawa, S Ishihara, A Ando…

文献索引：Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991

全文：HTML全文

被引用次数: 58

摘要

Chemical Research Laboratory, Sankyo Co., Ltd., Hiromachi, Shinagawa-ku, Tokyo 140, Japan. Received April 13, 1987 c~-[6-[[(S)-l-(Ethoxycarbonyl)-3-phenylpropyl] amino]-5- oxoperhydro-l, 4-thiazepin-4-yl] acetic acids (monoester monoacids) and their dicarboxylic acids having the hydrophobic substituents at the 2-or 3-position of the thiazepinone ring were prepared and assayed for angiotensin-converting enzyme (ACE) inhibitory activity. ...