A series of ring-alkoxylated and ringhydroxylated analogues of lucanthone was prepared and tested for antitumor activity. The most biologically interesting members of this group were the 7-hydroxylucanthone derivatives, 50 and 51, which gave T/C values in the NCI P- 388 antitumor screen of 188 and 265, respectively. The apparent association constants and AT,,, values for a number of analogueDNA complexes were determined to ascertain ...
![9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl Structure](https://image.chemsrc.com/caspic/276/80568-28-1.png)
![9H-Thioxanthen-9-one,1-[[3-(dimethylamino)propyl]amino]-4-hydroxy-, hydriodide (1:2) Structure](https://image.chemsrc.com/caspic/176/80568-62-3.png)
![9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide Structure](https://image.chemsrc.com/caspic/062/80568-65-6.png)
![6-hydroxy-1-[2-(2-hydroxyethylamino)ethylamino]-4-methyl-thioxanthen-9-one Structure](https://image.chemsrc.com/caspic/438/80568-46-3.png)
![9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-6-hydroxy-4-methyl-, hydriodide (1:1) Structure](https://image.chemsrc.com/caspic/400/80568-69-0.png)
![9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl Structure](https://image.chemsrc.com/caspic/031/80568-39-4.png)
