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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Ring-hydroxylated analogs of lucanthone as antitumor agents

S Archer, KJ Miller, R Rej, C Periana…

文献索引：Archer; Miller; Rej; Periana; Fricker Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227

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被引用次数: 36

摘要

A series of ring-alkoxylated and ringhydroxylated analogues of lucanthone was prepared and tested for antitumor activity. The most biologically interesting members of this group were the 7-hydroxylucanthone derivatives, 50 and 51, which gave T/C values in the NCI P- 388 antitumor screen of 188 and 265, respectively. The apparent association constants and AT,,, values for a number of analogueDNA complexes were determined to ascertain ...

but-2-enedioic acid; 1-(2-diethylaminoethylamino)-2-methoxy-4-methyl-thioxanthen-9-one结构式

but-2-enedioic ...

~66%

9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-2-hydroxy-4-methyl-结构式

9H-Thioxanthen-...

1-(2-diethylaminoethylamino)-5-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

~%

1-(2-diethylaminoethylamino)-5-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

2-氨基-3-甲氧基苯甲酸结构式

2-氨基-3-甲氧基苯甲酸

~%

1-(2-diethylaminoethylamino)-5-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

未登录结构式

~%

1-(2-diethylaminoethylamino)-5-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

2-氨基-5-甲氧基苯甲酸结构式

2-氨基-5-甲氧基苯甲酸

~%

1-(2-aminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-aminoethyl...

2-溴-4-氯甲苯结构式

2-溴-4-氯甲苯

~%

1-(2-aminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-aminoethyl...

2-疏基-5-甲氧基苯甲酸结构式

2-疏基-5-甲氧基苯甲酸

~%

1-(2-aminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-aminoethyl...

2,2-Dithiobis(5-methoxybenzoic acid)结构式

2,2-Dithiobis(5...

~%

1-(2-aminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-aminoethyl...

未登录结构式

~%

1-(2-aminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-aminoethyl...

未登录结构式

~%

1-(2-aminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-aminoethyl...

对氯甲苯结构式

~%

1-(2-aminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-aminoethyl...

未登录结构式

~%

1-(2-aminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-aminoethyl...

2-氨基-5-甲氧基苯甲酸结构式

2-氨基-5-甲氧基苯甲酸

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl-结构式

9H-Thioxanthen-...

2-溴-4-氯甲苯结构式

2-溴-4-氯甲苯

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl-结构式

9H-Thioxanthen-...

2-疏基-5-甲氧基苯甲酸结构式

2-疏基-5-甲氧基苯甲酸

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl-结构式

9H-Thioxanthen-...

2,2-Dithiobis(5-methoxybenzoic acid)结构式

2,2-Dithiobis(5...

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl-结构式

9H-Thioxanthen-...

未登录结构式

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl-结构式

9H-Thioxanthen-...

对氯甲苯结构式

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl-结构式

9H-Thioxanthen-...

未登录结构式

N,N-二甲基乙二胺结构式

N,N-二甲基乙二胺

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl-结构式

9H-Thioxanthen-...

对氯甲苯结构式

2,2-Dithiobis(5-methoxybenzoic acid)结构式

2,2-Dithiobis(5...

N,N-二甲基乙二胺结构式

N,N-二甲基乙二胺

~%

未登录结构式

详细

1-chloro-4-hydroxythioxanthen-9-one结构式

1-chloro-4-hydr...

~%

9H-Thioxanthen-9-one,1-[[3-(dimethylamino)propyl]amino]-4-hydroxy-, hydriodide (1:2)结构式

9H-Thioxanthen-...

对氯苯酚结构式

~%

9H-Thioxanthen-9-one,1-[[3-(dimethylamino)propyl]amino]-4-hydroxy-, hydriodide (1:2)结构式

9H-Thioxanthen-...

硫代水杨酸结构式

硫代水杨酸

~%

9H-Thioxanthen-9-one,1-[[3-(dimethylamino)propyl]amino]-4-hydroxy-, hydriodide (1:2)结构式

9H-Thioxanthen-...

4-(benzyloxy)-1-((3-(dimethylamino)propyl)amino)-9H-thioxanthen-9-one结构式

4-(benzyloxy)-1...

~%

9H-Thioxanthen-9-one,1-[[3-(dimethylamino)propyl]amino]-4-hydroxy-, hydriodide (1:2)结构式

9H-Thioxanthen-...

未登录结构式

~%

9H-Thioxanthen-9-one,1-[[3-(dimethylamino)propyl]amino]-4-hydroxy-, hydriodide (1:2)结构式

9H-Thioxanthen-...

对氯苯酚结构式

硫代水杨酸结构式

硫代水杨酸

~38%

1-chloro-4-hydroxythioxanthen-9-one结构式

1-chloro-4-hydr...

2-氨基-5-甲氧基苯甲酸结构式

2-氨基-5-甲氧基苯甲酸

~%

1-(2-dimethylaminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

2-溴-4-氯甲苯结构式

2-溴-4-氯甲苯

~%

1-(2-dimethylaminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

2-疏基-5-甲氧基苯甲酸结构式

2-疏基-5-甲氧基苯甲酸

~%

1-(2-dimethylaminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

2,2-Dithiobis(5-methoxybenzoic acid)结构式

2,2-Dithiobis(5...

~%

1-(2-dimethylaminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

未登录结构式

~%

1-(2-dimethylaminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-7-methoxy-4-methyl-结构式

9H-Thioxanthen-...

~%

1-(2-dimethylaminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

对氯甲苯结构式

~%

1-(2-dimethylaminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

未登录结构式

~%

1-(2-dimethylaminoethylamino)-7-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

2-氯-5-甲基苯酚结构式

2-氯-5-甲基苯酚

~%

1-(2-dimethylaminoethylamino)-2-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

未登录结构式

~%

1-(2-dimethylaminoethylamino)-2-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

硫代水杨酸结构式

硫代水杨酸

~%

1-(2-dimethylaminoethylamino)-2-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

2-(benzyloxy)-1-((2-(dimethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one结构式

2-(benzyloxy)-1...

~%

1-(2-dimethylaminoethylamino)-2-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

未登录结构式

~%

1-(2-dimethylaminoethylamino)-2-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

2-氨基-5-甲氧基苯甲酸结构式

2-氨基-5-甲氧基苯甲酸

~%

9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide结构式

9H-Thioxanthen-...

2-溴-4-氯甲苯结构式

2-溴-4-氯甲苯

~%

9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide结构式

9H-Thioxanthen-...

2-疏基-5-甲氧基苯甲酸结构式

2-疏基-5-甲氧基苯甲酸

~%

9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide结构式

9H-Thioxanthen-...

2,2-Dithiobis(5-methoxybenzoic acid)结构式

2,2-Dithiobis(5...

~%

9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide结构式

9H-Thioxanthen-...

未登录结构式

~%

9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide结构式

9H-Thioxanthen-...

1-(2-diethylaminoethylamino)-7-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

~%

9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide结构式

9H-Thioxanthen-...

对氯甲苯结构式

~%

9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide结构式

9H-Thioxanthen-...

未登录结构式

~%

9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-7-hydroxy-4-methyl-, monohydriodide结构式

9H-Thioxanthen-...

2-溴-4-氯甲苯结构式

2-溴-4-氯甲苯

~%

6-hydroxy-1-[2-(2-hydroxyethylamino)ethylamino]-4-methyl-thioxanthen-9-one结构式

6-hydroxy-1-[2-...

2-MERCAPTO-4-METHOXYBENZOIC ACID结构式

2-MERCAPTO-4-ME...

~%

6-hydroxy-1-[2-(2-hydroxyethylamino)ethylamino]-4-methyl-thioxanthen-9-one结构式

6-hydroxy-1-[2-...

1-chloro-6-methoxy-4-methylthioxanthenone结构式

1-chloro-6-meth...

~%

6-hydroxy-1-[2-(2-hydroxyethylamino)ethylamino]-4-methyl-thioxanthen-9-one结构式

6-hydroxy-1-[2-...

未登录结构式

~%

6-hydroxy-1-[2-(2-hydroxyethylamino)ethylamino]-4-methyl-thioxanthen-9-one结构式

6-hydroxy-1-[2-...

1-chloro-6-methoxy-4-methylthioxanthenone结构式

1-chloro-6-meth...

羟乙基乙二胺结构式

羟乙基乙二胺

~%

6-hydroxy-1-[2-(2-hydroxyethylamino)ethylamino]-4-methyl-thioxanthen-9-one结构式

6-hydroxy-1-[2-...

1-((2-(dimethylamino)ethyl)amino)-5-methoxy-4-methyl-9H-thioxanthen-9-one结构式

1-((2-(dimethyl...

~%

1-(2-dimethylaminoethylamino)-5-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

2-氨基-3-甲氧基苯甲酸结构式

2-氨基-3-甲氧基苯甲酸

~%

1-(2-dimethylaminoethylamino)-5-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

未登录结构式

~%

1-(2-dimethylaminoethylamino)-5-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

1-chloro-4-hydroxythioxanthen-9-one结构式

1-chloro-4-hydr...

~%

1-(2-diethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-diethylami...

对氯苯酚结构式

~%

1-(2-diethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-diethylami...

硫代水杨酸结构式

硫代水杨酸

~%

1-(2-diethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-diethylami...

4-(benzyloxy)-1-((2-(diethylamino)ethyl)amino)-9H-thioxanthen-9-one结构式

4-(benzyloxy)-1...

~%

1-(2-diethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-diethylami...

未登录结构式

~%

1-(2-diethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-diethylami...

2-溴-4-氯甲苯结构式

2-溴-4-氯甲苯

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-6-hydroxy-4-methyl-, hydriodide (1:1)结构式

9H-Thioxanthen-...

2-MERCAPTO-4-METHOXYBENZOIC ACID结构式

2-MERCAPTO-4-ME...

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-6-hydroxy-4-methyl-, hydriodide (1:1)结构式

9H-Thioxanthen-...

1-chloro-6-methoxy-4-methylthioxanthenone结构式

1-chloro-6-meth...

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-6-hydroxy-4-methyl-, hydriodide (1:1)结构式

9H-Thioxanthen-...

未登录结构式

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-6-hydroxy-4-methyl-, hydriodide (1:1)结构式

9H-Thioxanthen-...

2-氨基-5-甲氧基苯甲酸结构式

2-氨基-5-甲氧基苯甲酸

~%

1-(2-diethylaminoethylamino)-7-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

2-溴-4-氯甲苯结构式

2-溴-4-氯甲苯

~%

1-(2-diethylaminoethylamino)-7-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

2-疏基-5-甲氧基苯甲酸结构式

2-疏基-5-甲氧基苯甲酸

~%

1-(2-diethylaminoethylamino)-7-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

2,2-Dithiobis(5-methoxybenzoic acid)结构式

2,2-Dithiobis(5...

~%

1-(2-diethylaminoethylamino)-7-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

未登录结构式

~%

1-(2-diethylaminoethylamino)-7-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

对氯甲苯结构式

~%

1-(2-diethylaminoethylamino)-7-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

未登录结构式

N,N-二乙基乙二胺结构式

N,N-二乙基乙二胺

~%

1-(2-diethylaminoethylamino)-7-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

未登录结构式

~%

9H-Thioxanthen-9-one,1-[[2-(dimethylamino)ethyl]amino]-6-hydroxy-4-methyl-, hydriodide (1:1)结构式

9H-Thioxanthen-...

4-氯-3-甲氧基甲苯结构式

4-氯-3-甲氧基甲苯

~%

1-(2-dimethylaminoethylamino)-2-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

硫代水杨酸结构式

硫代水杨酸

~%

1-(2-dimethylaminoethylamino)-2-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-dimethylam...

2-氨基-5-甲氧基苯甲酸结构式

2-氨基-5-甲氧基苯甲酸

~%

9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl-结构式

9H-Thioxanthen-...

2-溴-4-氯甲苯结构式

2-溴-4-氯甲苯

~%

9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl-结构式

9H-Thioxanthen-...

2-疏基-5-甲氧基苯甲酸结构式

2-疏基-5-甲氧基苯甲酸

~%

9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl-结构式

9H-Thioxanthen-...

2,2-Dithiobis(5-methoxybenzoic acid)结构式

2,2-Dithiobis(5...

~%

9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl-结构式

9H-Thioxanthen-...

未登录结构式

~%

9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl-结构式

9H-Thioxanthen-...

对氯甲苯结构式

~%

9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl-结构式

9H-Thioxanthen-...

未登录结构式

~%

9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl-结构式

9H-Thioxanthen-...

羟乙基乙二胺结构式

羟乙基乙二胺

未登录结构式

~%

9H-Thioxanthen-9-one, 7-hydroxy-1-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-4-methyl-结构式

9H-Thioxanthen-...

2-氨基-3-甲氧基苯甲酸结构式

2-氨基-3-甲氧基苯甲酸

~%

1-(2-diethylaminoethylamino)-5-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

未登录结构式

~%

1-(2-diethylaminoethylamino)-5-methoxy-4-methyl-thioxanthen-9-one结构式

1-(2-diethylami...

未登录结构式

~%

1-(3-diethylaminopropylamino)-2-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(3-diethylami...

4-氯-3-甲氧基甲苯结构式

4-氯-3-甲氧基甲苯

~%

1-(3-diethylaminopropylamino)-2-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(3-diethylami...

硫代水杨酸结构式

硫代水杨酸

~%

1-(3-diethylaminopropylamino)-2-hydroxy-4-methyl-thioxanthen-9-one结构式

1-(3-diethylami...

1-chloro-4-hydroxythioxanthen-9-one结构式

1-chloro-4-hydr...

~%

1-(2-dimethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-dimethylam...

对氯苯酚结构式

~%

1-(2-dimethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-dimethylam...

硫代水杨酸结构式

硫代水杨酸

~%

1-(2-dimethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-dimethylam...

4-(benzyloxy)-1-((2-(dimethylamino)ethyl)amino)-9H-thioxanthen-9-one结构式

4-(benzyloxy)-1...

~34%

1-(2-dimethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-dimethylam...

未登录结构式

~%

1-(2-dimethylaminoethylamino)-4-hydroxy-thioxanthen-9-one结构式

1-(2-dimethylam...