Synthesis

A domino copper-catalyzed CN and CO cross-coupling for the conversion of primary amides into oxazoles

K Schuh, F Glorius

Index: Schuh, Kerstin; Glorius, Frank Synthesis, 2007 , # 15 p. 2297 - 2306

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Citation Number: 37

Abstract

Abstract A variety of oxazoles can efficiently be prepared, in a single step and in good yield, from primary amides and 1, 2-dihaloalkenes using copper-catalysis. This new method allows the regioselective formation of a range of substituted oxazoles. The required 1, 2- dihaloalkenes can prepared by simple treatment of alkynes with elemental bromine or iodine.

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