Synthesis

A domino copper-catalyzed CN and CO cross-coupling for the conversion of primary amides into oxazoles

K Schuh, F Glorius

文献索引：Schuh, Kerstin; Glorius, Frank Synthesis, 2007 , # 15 p. 2297 - 2306

被引用次数: 37

摘要

Abstract A variety of oxazoles can efficiently be prepared, in a single step and in good yield, from primary amides and 1, 2-dihaloalkenes using copper-catalysis. This new method allows the regioselective formation of a range of substituted oxazoles. The required 1, 2- dihaloalkenes can prepared by simple treatment of alkynes with elemental bromine or iodine.

~93%

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~49%

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~21%

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~91%

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~7%

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~36%

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~8%

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~12%

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~10%

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~63%

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