盐酸依托拉嗪

• 常用名: 盐酸依托拉嗪
• 英文名: Eltoprazine (hydrochloride)
• CAS号: 98206-09-8
• 分子量: 256.72900
• 密度: 1.18g/cm3
• 沸点: 384.3ºC at 760 mmHg
• 分子式: C₁₂H₁₇ClN₂O₂
• 熔点: N/A
• 闪点: 186.2ºC

盐酸依托拉嗪用途

Eltoprazine(DU28853)盐酸盐是5-HT1A和5-HT1B受体激动剂，同时是5-HT2C受体拮抗剂。

盐酸依托拉嗪名称

• 中文名: 1-(2,3-二氢-1,4-苯并二氧烷-5-基)-哌嗪盐酸盐
• 英文名: 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine

盐酸依托拉嗪生物活性

• 描述: Eltoprazine(DU28853)盐酸盐是5-HT1A和5-HT1B受体激动剂,同时是5-HT2C受体拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177(1-2):55-66.

  [2]. Joels M, et al. Eltoprazine suppresses hyperpolarizing responses to serotonin in rat hippocampus. J Pharmacol Exp Ther. 1990 Apr;253(1):284-9.

  [3]. Bezard E, et al. Study of the antidyskinetic effect of eltoprazine in animal models of levodopa-induced dyskinesia. Mov Disord. 2013 Jul;28(8):1088-96.

  [4]. Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262(1-2):125-31.

盐酸依托拉嗪物理化学性质

• 密度: 1.18g/cm3
• 沸点: 384.3ºC at 760 mmHg
• 分子式: C₁₂H₁₇ClN₂O₂
• 分子量: 256.72900
• 闪点: 186.2ºC
• 精确质量: 256.09800
• PSA: 33.73000
• LogP: 2.06320
• 折射率: 1.562
• 储存条件: -20°C，密闭，干燥

盐酸依托拉嗪英文别名

• Eltoprazinum [Latin]
• Eltoprazine
• Eltoprazina
• Eltoprazina [Spanish]
• 1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine
• Eltoprazine hydrochloride
• Eltoprazine (hydrochloride)