S()-雷氯必利 (+)-酒石酸盐结构式
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常用名 | S()-雷氯必利 (+)-酒石酸盐 | 英文名 | Raclopride tartrate |
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CAS号 | 98185-20-7 | 分子量 | 497.32400 | |
密度 | N/A | 沸点 | N/A | |
分子式 | C19H26Cl2N2O9 | 熔点 | N/A | |
MSDS | 美版 | 闪点 | N/A |
S()-雷氯必利 (+)-酒石酸盐用途酒石酸拉克洛普利是一种选择性多巴胺D2/D3受体拮抗剂,具有潜在的抗精神病作用。酒石酸拉氯普利特分别以1.8nm和3.5nm的Kis与D2和D3受体结合[1][2]。 |
中文名 | S(-)-雷氯必利(+)-酒石酸盐 |
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英文名 | (S)-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamide L-(+)-tartrate |
英文别名 | 更多 |
描述 | 酒石酸拉克洛普利是一种选择性多巴胺D2/D3受体拮抗剂,具有潜在的抗精神病作用。酒石酸拉氯普利特分别以1.8nm和3.5nm的Kis与D2和D3受体结合[1][2]。 |
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相关类别 | |
靶点 |
D2 Receptor:1.8 nM (Ki) D3 Receptor:3.5 nM (Ki) D4 Receptor:2400 nM (Ki) D1 Receptor:18000 nM (Ki) |
体内研究 | 酒石酸Raclopride(0.1、0.3或0.6 mg/kg;IP;30分钟;O1系白化雄性小鼠)显著减少分配给攻击行为的时间[2]。 |
参考文献 |
[1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994;15(7):264-270. |
分子式 | C19H26Cl2N2O9 |
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分子量 | 497.32400 |
精确质量 | 496.10200 |
PSA | 176.86000 |
LogP | 1.12790 |
外观性状 | 固体 |
储存条件 | 室温 |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危险品运输编码 | NONH for all modes of transport |
RTECS号 | CV3465000 |
Effect of raclopride on dopamine D2 receptor mRNA expression in rat brain.
Neuroscience 47 , 771-779, (1992) Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this... |
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Chronic treatment with the D1 receptor antagonist, SCH 23390, and the D2 receptor antagonist, raclopride, in cebus monkeys withdrawn from previous haloperidol treatment. Extrapyramidal syndromes and dopaminergic supersensitivity.
Psychopharmacology 112 , 389-397, (1993) The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 2339... |
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Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents.
Eur. J. Pharmacol. 271 , 167, (1994) S 14506 (1-[-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piper azine hydrochloride), 8-OH-DPAT ((+/-)-8-hydroxydipropylaminotetralin hydrobromide), clozapine and raclopride were compared in some... |
(S)-2-[(3,5-dichloro-6-methoxy-2-hydroxybenzamido)methyl]-1-ethylpyrrolidine L-tartrate |
raclopride tartarate |
raclopride tartrate |
(S)-2-[(3,5-dichloro-6-methoxy-2-hydroxybenzamido)methyl]-1-ethylpyrrolidine L-tartrate |
S(-)-RACLOPRIDE (+)-TARTRATE SALT |