BNC105

• 常用名: BNC105
• 英文名: BNC105
• CAS号: 945771-74-4
• 分子量: 372.36900
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₀O₇
• 熔点: N/A
• 闪点: N/A

BNC105用途

BNC105是新乡微管多聚抑制剂，抗肿瘤和血管阻断剂。

BNC105名称

• 中文名: BNC105
• 英文名: (7-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone

BNC105生物活性

• 描述: BNC105是新乡微管多聚抑制剂,抗肿瘤和血管阻断剂。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27.

  [2]. Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73.

  [3]. Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60.

BNC105物理化学性质

• 分子式: C₂₀H₂₀O₇
• 分子量: 372.36900
• 精确质量: 372.12100
• PSA: 87.36000
• LogP: 3.71220
• InChIKey: RADMJHVVIZTENA-UHFFFAOYSA-N
• SMILES: COc1cc(C(=O)c2c(C)oc3c(O)c(OC)ccc23)cc(OC)c1OC
• 储存条件: 2-8℃

BNC105英文别名

• 2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan
• (7-hydroxy-6-methoxy-2-methylbenzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone
• UNII-Z3S2Z6H7B0
• 2-methyl-3-(3,4,5-trimethoxybenzoyl)-7-hydroxy-6-methoxy-benzo[b]furan
• 2-methyl-3-(3,4,5-trimethoxybenzoyl)-6-methoxy-7-hydroxy-benzo[b]furan
• 2-methyl-7-hydroxy-3-(3,4,5-trimethoxybenzoyl)-6-methoxybenzofuran
• BNC105