GMI-1070

• 常用名: GMI-1070
• 英文名: GMI-1070
• CAS号: 927881-99-0
• 分子量: 1447.425
• 密度: 1.7±0.1 g/cm3
• 沸点: N/A
• 分子式: C₅₈H₇₄N₆O₃₁S₃
• 熔点: N/A
• 闪点: N/A

GMI-1070用途

Rivipansel(GMI-1070)是一种有效的E-选择素拮抗剂。Rivipansel防止白细胞和血管内皮之间的相互作用。Rivipansel具有研究镰状细胞血管闭塞危象的潜力[1][2]。

GMI-1070名称

• 英文名: Rivipansel

GMI-1070生物活性

• 描述: Rivipansel(GMI-1070)是一种有效的E-选择素拮抗剂。Rivipansel防止白细胞和血管内皮之间的相互作用。Rivipansel具有研究镰状细胞血管闭塞危象的潜力[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Dampier CD, et al. A Randomized Clinical Trial of the Efficacy and Safety of Rivipansel for Sickle Cell Vaso-occlusive Crisis (VOC). Blood. 2022 Aug 18:blood.2022015797.

  [2]. Carlton D.DampierMD, et al. Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: Reset Clinical Trial Analysis. Blood, 2020, 136 (1):18-19.

GMI-1070物理化学性质

• 密度: 1.7±0.1 g/cm3
• 分子式: C₅₈H₇₄N₆O₃₁S₃
• 分子量: 1447.425
• 精确质量: 1446.356079
• LogP: -0.62
• InChIKey: VXBNTHRZPJLRSS-PTCSXESPSA-N
• SMILES: CC1OC(OC2C(NC(=O)c3cc(=O)[nH]c(=O)[nH]3)CC(C(=O)NCCNC(=O)COCCOCC(=O)Nc3cc(S(=O)(=O)O)cc4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)CC2OC2OC(CO)C(O)C(OC(CC3CCCCC3)C(=O)O)C2OC(=O)c2ccccc2)C(O)C(O)C1O
• 折射率: 1.693

GMI-1070英文别名

• 4B115V09LB
• GMI-1070
• PF-06460031
• (1R,2R,3S,5R)-2-[(6-Deoxy-α-L-galactopyranosyl)oxy]-3-{[(2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)carbonyl]amino}-5-[(2-{[(2-{2-oxo-2-[(3,6,8-trisulfo-1-naphthyl)amino]ethoxy}ethoxy)acetyl]amino }ethyl)carbamoyl]cyclohexyl 2-O-benzoyl-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-β-D-galactopyranoside
• 9776
• β-D-Galactopyranoside, (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-3-[[(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)carbonyl]amino]-5-[1,6,13-trioxo-13-[(3,6,8-trisulfo-1-naphthalenyl)am ino]-8,11-dioxa-2,5-diazatridec-1-yl]cyclohexyl 3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-, 2-benzoate
• Rivipansel