1914993-95-5

1914993-95-5结构式

常用中文名：GMI-1271
常用英文名：GMI-1271
CAS号：1914993-95-5
分子式：C₆₀H₁₀₈N₃NaO₂₇
分子量：1326.493
相关类别：信号通路细胞骨架 Integrin
发布时间：2020-01-12 09:58:50
更新时间：2025-08-24 19:26:36
一种新型特异性糖模拟E-选择素拮抗剂,Kd为0.46 uM,IC50为1.75 uM；弱抑制L-选择素(IC50=2.9 uM),P-选择素>10 uM；不仅可以将AML细胞移出保护性生态位而且还阻断NF-κB活化并阻止这种E-选择素介导的化学抗性,从而增强标准化疗的治疗效果；也克服MM转移和化学抗性。血癌2期临床

英文名	Sodium (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-3-ethyl-5-[(38-oxo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxa-39-azahentetracontan-41-yl)carbamoyl]cyclohexyl 2-acetamido-3-O-[(1S)-1-carboxylato-2-cyclohexylethyl]-2-deoxy-β-D-galactopyranoside
英文别名	Sodium (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-3-ethyl-5-[(38-oxo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxa-39-azahentetracontan-41-yl)carbamoyl]cyclohexyl 2-acetamido-3-O-[(1S)-1-car boxylato-2-cyclohexylethyl]-2-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-5-(1,6-dioxo-9,12,15,18,21,24,27,30,33,36,39,42-dodecaoxa-2,5-diazatritetracont-1-yl)-3-ethylcyclohexyl 2-(acetylamino )-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-2-deoxy-, sodium salt (1:1)

描述	一种新型特异性糖模拟E-选择素拮抗剂,Kd为0.46 uM,IC50为1.75 uM；弱抑制L-选择素(IC50=2.9 uM),P-选择素>10 uM；不仅可以将AML细胞移出保护性生态位而且还阻断NF-κB活化并阻止这种E-选择素介导的化学抗性,从而增强标准化疗的治疗效果；也克服MM转移和化学抗性。血癌2期临床
参考文献	References 1. Price TT, et al. Mol Cell Oncol. 2016 Jul 26;4(4):e1214771. 2. Culmer DL, et al. Thromb Haemost. 2017 Jun 2;117(6):1171-1181. 3. Natoni A, et al. Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.123. 4. Dutta P, et al. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1802-8. View Related Products by Target Selectin Blood Cancer