Rifaquizinone

• 常用名: Rifaquizinone
• 英文名: Rifaquizinone
• CAS号: 922717-97-3
• 分子量: 1205.37
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₆₅H₈₁FN₆O₁₅
• 熔点: N/A
• 闪点: N/A

Rifaquizinone用途

Rifaquizinone (CBR-2092) 是一种利福霉素-喹诺酮混合抗生素。Rifaquizinone 抑制野生型金黄色葡萄球菌 RNA 聚合酶,IC50 为 34 nM。Rifaquizinone 有效抑制金黄色葡萄球菌感染,对 300 种葡萄球菌和链球菌临床分离株的 MIC 范围为 0.008-0.5 μg/mL。

Rifaquizinone名称

• 英文名: 8-[(3R)-3-{1-[{1-[(E)-{[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-Acetoxy-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-26-yl]methylene}amino]-4-piperidinyl}(methyl)amino]cyclopropyl}-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid

Rifaquizinone生物活性

• 描述: Rifaquizinone (CBR-2092) 是一种利福霉素-喹诺酮混合抗生素。Rifaquizinone 抑制野生型金黄色葡萄球菌 RNA 聚合酶,IC50 为 34 nM。Rifaquizinone 有效抑制金黄色葡萄球菌感染,对 300 种葡萄球菌和链球菌临床分离株的 MIC 范围为 0.008-0.5 μg/mL。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Robertson GT, et al. In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. Antimicrob Agents Chemother. 2008 Jul;52(7):2313-23.

  [2]. Robertson GT, et al. In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci. Antimicrob Agents Chemother. 2008 Jul;52(7):2324-34.

Rifaquizinone物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₆₅H₈₁FN₆O₁₅
• 分子量: 1205.37
• 精确质量: 1204.574341
• LogP: 3.56
• InChIKey: OPZFMLLAJBIKAN-YSBZUPOXSA-N
• SMILES: COC1C=COC2(C)Oc3c(C)c(O)c4c(O)c(c(C=NN5CCC(N(C)C6(C7CCN(c8c(F)cn9c(=O)c(C(=O)O)cc(C%10CC%10)c9c8C)C7)CC6)CC5)c(O)c4c3C2=O)NC(=O)C(C)=CC=CC(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C
• 折射率: 1.665

Rifaquizinone英文别名

• 8-[(3R)-3-{1-[{1-[(E)-{[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-Acetoxy-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1 4,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-26-yl]methylene}amino]-4-piperidinyl}(methyl)amino]cyclopropyl}-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxy
 lic acid
• 4H-Quinolizine-3-carboxylic acid, 8-[(3R)-3-[1-[[1-[[(1E)-[(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(acetyloxy)-1,2-dihydro-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxy[1,11,13]pentadecatrienoimino)naphtho[2,1-b]furan-8-yl]methylene]amino]-4-piperidinyl]methylamino]cyclopropyl]-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-