枸橼酸托瑞米芬

• 常用名: 枸橼酸托瑞米芬
• 英文名: Toremifene Citrate
• CAS号: 89778-27-8
• 分子量: 598.083
• 密度: 1.045g/cm3
• 沸点: 535.1ºC at 760 mmHg
• 分子式: C₃₂H₃₆ClNO₈
• 熔点: 158-164ºC
• 闪点: 277.4ºC
• 符号: GHS05, GHS07, GHS09
• 信号词: Danger

枸橼酸托瑞米芬用途

Toremifene(NK 622; FC 1157a)柠檬酸盐是第二代选择性雌激素受体调节剂,对雌激素受体的IC50为1μM。

枸橼酸托瑞米芬名称

• 中文名: 枸橼酸托瑞米芬
• 英文名: Toremifene Citrate
• 中文别名: 2(4-(4-氯-1,2-二苯基-1-丁烯基)苯氧基-N,N-二甲基乙胺枸橼酸盐 | 柠檬酸托瑞米芬 | 2[4-(4-氯-1,2-二苯基-1-丁烯基)苯氧基-N,N-二甲基乙胺枸橼酸盐

枸橼酸托瑞米芬生物活性

• 描述: Toremifene(NK 622; FC 1157a)柠檬酸盐是第二代选择性雌激素受体调节剂,对雌激素受体的IC50为1μM。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 癌症
• 参考文献:

  [1]. Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7(Suppl 3): S30-S35.

  [2]. Gauri J Sabnis, Luciana Macedo, Olga Goloubeva, Toremifene - Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model. J Steroid Biochem Mol Biol. 2008 January; 108(1-2): 1-7.

  [3]. Taneja SS, Morton R, Barnette G, Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene. J Clin Oncol. 2013 Feb 10;31(5):523-9.

枸橼酸托瑞米芬物理化学性质

• 密度: 1.045g/cm3
• 沸点: 535.1ºC at 760 mmHg
• 熔点: 158-164ºC
• 分子式: C₃₂H₃₆ClNO₈
• 分子量: 598.083
• 闪点: 277.4ºC
• 精确质量: 597.212952
• PSA: 144.60000
• LogP: 4.96650
• InChIKey: IWEQQRMGNVVKQW-OQKDUQJOSA-N
• SMILES: CN(C)CCOc1ccc(C(=C(CCCl)c2ccccc2)c2ccccc2)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O
• 外观性状: 白色或近乎于白色粉末
• 折射率: 1.416-1.418
• 储存条件: -20°C Freezer
• 水溶解性: DMSO: >10mg/mL

枸橼酸托瑞米芬毒性和生态

枸橼酸托瑞米芬安全信息

• 符号: GHS05, GHS07, GHS09
• 信号词: Danger
• 危害声明: H302-H318-H410
• 警示性声明: P280-P301 + P312 + P330-P305 + P351 + P338 + P310
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-37/39
• 危险品运输编码: UN 3077 9 / PGIII
• RTECS号: KH2156700
• 海关编码: 2942000000

枸橼酸托瑞米芬海关

• 海关编码: 2942000000

枸橼酸托瑞米芬英文别名

• 2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine,2-hydroxypropane-1,2,3-tricarboxylic acid
• 2-{4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate (salt)
• 2-{4-[(1Z)-4-Chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
• 2-{4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• Toremifene Citrate
• 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)
• ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
• 2-Hydroxypropan-1,2,3-tricarbonsäure--2-{4-[(1Z)-4-chlor-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamin(1:1)
• acide 2-hydroxypropane-1,2,3-tricarboxylique - 2-{4-[(1Z)-4-chloro-1,2-diphénylbut-1-én-1-yl]phénoxy}-N,N-diméthyléthanamine (1:1)
• Ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
• Toremifene (Citrate)