竹节香附素A

• 常用名: 竹节香附素A
• 英文名: Raddeanin A
• CAS号: 89412-79-3
• 分子量: 897.097
• 密度: 1.4±0.1 g/cm3
• 沸点: 967.2±65.0 °C at 760 mmHg
• 分子式: C₄₇H₇₆O₁₆
• 熔点: N/A
• 闪点: 276.2±27.8 °C

竹节香附素A用途

Raddeanin A 是竹节香附中天然的三萜皂苷,具有抗癌活性。Raddeanin A 通过 ROS/JNK 和 NF-κB 信号通路对人类骨肉瘤产生抗癌效应。

竹节香附素A名称

• 中文名: 竹节香附素A
• 英文名: 10-[3-[4,5-dihydroxy-6-(hydroxymethyl)-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• 中文别名: 银莲花素A | 竹叶香附素A

竹节香附素A生物活性

• 描述: Raddeanin A 是竹节香附中天然的三萜皂苷,具有抗癌活性。Raddeanin A 通过 ROS/JNK 和 NF-κB 信号通路对人类骨肉瘤产生抗癌效应。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Ma B, et al. Raddeanin A, a natural triterpenoid saponin compound, exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway. Toxicol Appl Pharmacol. 2018 Aug 15;353:87-101.

  [2]. Guo SS, et al. Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil resistance in cholangiocarcinoma cells. 3.411World J Gastroenterol. 2019 Jul 14;25(26):3380-3391.

  [3]. Xia H, et al. Raddeanin A down-regulates androgen receptor and its splice variants in prostate cancer. J Cell Mol Med. 2019 May;23(5):3656-3664.

  [4]. Meng C, et al. Raddeanin A Induces Apoptosis and Cycle Arrest in Human HCT116 Cells through PI3K/AKT Pathway Regulation In Vitro and In Vivo. Evid Based Complement Alternat Med. 2019 May 26;2019:7457105.

竹节香附素A物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 967.2±65.0 °C at 760 mmHg
• 分子式: C₄₇H₇₆O₁₆
• 分子量: 897.097
• 闪点: 276.2±27.8 °C
• 精确质量: 896.513306
• PSA: 254.52000
• LogP: 10.11
• InChIKey: VQQGPFFHGWNIGX-PPCHTBMASA-N
• SMILES: CC1OC(OC2C(OC3C(OC4CCC5(C)C(CCC6(C)C5CC=C5C7CC(C)(C)CCC7(C(=O)O)CCC56C)C4(C)C)OCC(O)C3O)OC(CO)C(O)C2O)C(O)C(O)C1O
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.610
• 储存条件: 室温

竹节香附素A安全信息

• 安全声明 (欧洲): 24/25

竹节香附素A英文别名

• Isolate from Anemone raddeana regel
• Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-β-D-glucopyranosyl-(1->;2)-α-L-arabinopyranosyl]oxy]-, (3β)-
• RaddeaninA
• (3β)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-β-D-glucopyranosyl-(1->2)-α-L-arabinopyranosyl]oxy}olean-12-en-28-oic acid