89412-79-3

• 常用中文名：竹节香附素A
• 常用英文名：Raddeanin A
• CAS号：89412-79-3
• 分子式：C₄₇H₇₆O₁₆
• 分子量：897.097
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-08-22 17:15:18
• 更新时间：2025-08-21 06:50:07
• Raddeanin A 是竹节香附中天然的三萜皂苷,具有抗癌活性。Raddeanin A 通过 ROS/JNK 和 NF-κB 信号通路对人类骨肉瘤产生抗癌效应。

名称

• 中文名: 竹节香附素A
• 英文名: 10-[3-[4,5-dihydroxy-6-(hydroxymethyl)-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• 中文别名: 银莲花素A; 竹叶香附素A
• 英文别名: Isolate from Anemone raddeana regel; Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-β-D-glucopyranosyl-(1->;2)-α-L-arabinopyranosyl]oxy]-, (3β)-; RaddeaninA; (3β)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-β-D-glucopyranosyl-(1->2)-α-L-arabinopyranosyl]oxy}olean-12-en-28-oic acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 967.2±65.0 °C at 760 mmHg
• 分子式: C₄₇H₇₆O₁₆
• 分子量: 897.097
• 闪点: 276.2±27.8 °C
• 精确质量: 896.513306
• PSA: 254.52000
• LogP: 10.11
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.610
• 储存条件: 室温

生物活性

• 描述: Raddeanin A 是竹节香附中天然的三萜皂苷,具有抗癌活性。Raddeanin A 通过 ROS/JNK 和 NF-κB 信号通路对人类骨肉瘤产生抗癌效应。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Ma B, et al. Raddeanin A, a natural triterpenoid saponin compound, exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway. Toxicol Appl Pharmacol. 2018 Aug 15;353:87-101.

  [2]. Guo SS, et al. Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil resistance in cholangiocarcinoma cells. 3.411World J Gastroenterol. 2019 Jul 14;25(26):3380-3391.

  [3]. Xia H, et al. Raddeanin A down-regulates androgen receptor and its splice variants in prostate cancer. J Cell Mol Med. 2019 May;23(5):3656-3664.

  [4]. Meng C, et al. Raddeanin A Induces Apoptosis and Cycle Arrest in Human HCT116 Cells through PI3K/AKT Pathway Regulation In Vitro and In Vivo. Evid Based Complement Alternat Med. 2019 May 26;2019:7457105.

安全

• 安全声明 (欧洲): 24/25

合成路线

124961-61-1 ~% 89412-79-3 109606-00-0

文献：Chemical and pharmaceutical bulletin, , vol. 37, # 9 p. 2445 - 2447

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