LY2334737

• 常用名: LY2334737
• 英文名: LY2334737
• CAS号: 892128-60-8
• 分子量: 389.39400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₅F₂N₃O₅
• 熔点: N/A
• 闪点: N/A

LY2334737用途

LY2334737是口服活性的gemcitabine原药。

LY2334737名称

• 中文名: 2'-脱氧-2',2'-二氟-N-(1-氧代-2-丙基戊基)胞苷
• 英文名: N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-propylpentanamide

LY2334737生物活性

• 描述: LY2334737是口服活性的gemcitabine原药。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 癌症
• 参考文献:

  [1]. Pratt SE, et al. Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells. Clin Cancer Res. 2013 Mar 1;19(5):1159-68.

  [2]. Koolen SL, et al. Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors. Clin Cancer Res. 2011 Sep 15;17(18):6071-82.

  [3]. Francia G, et al. Low-dose metronomic oral dosing of a prodrug of gemcitabine (LY2334737) causes antitumor effects in the absence of inhibition of systemic vasculogenesis. Mol Cancer Ther. 2012 Mar;11(3):680-9.

LY2334737物理化学性质

• 分子式: C₁₇H₂₅F₂N₃O₅
• 分子量: 389.39400
• 精确质量: 389.17600
• PSA: 117.17000
• LogP: 1.11830
• InChIKey: MEOYFIHNRBNEPI-UXIGCNINSA-N
• SMILES: CCCC(CCC)C(=O)Nc1ccn(C2OC(CO)C(O)C2(F)F)c(=O)n1
• 储存条件: 2-8℃

LY2334737英文别名

• unii-ylr364xysa
• LY2334737