沃诺拉赞

• 常用名: 沃诺拉赞
• 英文名: Vonoprazan
• CAS号: 881681-00-1
• 分子量: 345.391
• 密度: 1.3±0.1 g/cm3
• 沸点: 530.3±60.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆FN₃O₂S
• 熔点: N/A
• 闪点: 274.5±32.9 °C

沃诺拉赞用途

TAK-438 (free base)是一种新型的钾竞争性的酸阻断剂,可逆抑制H+/K+,ATPase,IC50为19 nM (pH 6.5)。

沃诺拉赞名称

• 中文名: 凡诺帕胺
• 英文名: Vonoprazan
• 中文别名: 沃诺拉赞

沃诺拉赞生物活性

• 描述: TAK-438 (free base)是一种新型的钾竞争性的酸阻断剂,可逆抑制H+/K+,ATPase,IC50为19 nM (pH 6.5)。
• 相关类别:
  信号通路 >> 跨膜转运 >> 质子泵
  研究领域 >> 内分泌
• 参考文献:

  [1]. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.

  [2]. Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.

  [3]. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.

沃诺拉赞物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 530.3±60.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆FN₃O₂S
• 分子量: 345.391
• 闪点: 274.5±32.9 °C
• 精确质量: 345.094727
• LogP: 2.74
• InChIKey: BFDBKMOZYNOTPK-UHFFFAOYSA-N
• SMILES: CNCc1cc(-c2ccccc2F)n(S(=O)(=O)c2cccnc2)c1
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.622

沃诺拉赞英文别名

• 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-
• Vonoprazan
• 1-[5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine
• TAK-438