Neuromedin B.结构式
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常用名 | Neuromedin B. | 英文名 | Neuromedin B trifluoroacetate salt |
|---|---|---|---|---|
| CAS号 | 87096-84-2 | 分子量 | 1132.29000 | |
| 密度 | 1.337 g/cm3 | 沸点 | 1697.4ºC | |
| 分子式 | C52H73N15O12S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 980.3ºC |
Neuromedin B.用途
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Neuromedin B 是一种含10个氨基酸的神经肽,属于蛙肽家族,为铃蟾肽相关肽。 |
| 中文名 | GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 |
|---|---|
| 英文名 | Neuromedin B (porcine) |
| 英文别名 | 更多 |
| 描述 | Neuromedin B 是一种含10个氨基酸的神经肽,属于蛙肽家族,为铃蟾肽相关肽。 |
|---|---|
| 相关类别 | |
| 体外研究 | 用于刺激大鼠子宫平滑肌收缩的效力(用作分离Neuromedin B(NMB)的生物测定法)与Bombesin(BN)进行比较。以BN为100,以摩尔计算的相对效力对于GRP为48％,对于NMB为4.9％。 NMB对大鼠胃条也具有收缩活性,但效力(引起50％最大反应所需的肽浓度比; EC50)仅为BN的5％(NMB的ECN = EC50)和约10％的GRP( NMB的GRP/EC50的EC50)[1]。 |
| 体内研究 | NMB和GRP对野生型和NMB-R缺陷小鼠眼底平滑肌收缩的影响,野生型小鼠和NMB-的ED50分别为14.4±2.3(n = 8)和10.9±2.3(n = 8) R缺陷小鼠分别为[1]。 |
| 参考文献 |
[1]. Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312. |
| 密度 | 1.337 g/cm3 |
|---|---|
| 沸点 | 1697.4ºC |
| 分子式 | C52H73N15O12S |
| 分子量 | 1132.29000 |
| 闪点 | 980.3ºC |
| 精确质量 | 1131.53000 |
| PSA | 464.10000 |
| LogP | 2.05180 |
| 折射率 | 1.613 |
| 储存条件 | -20°C |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危害码 (欧洲) | Xi |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3.0 |
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Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice.
Endocrinology 155(7) , 2492-9, (2014) The hypothalamic-pituitary-adrenal (HPA) axis is a major part of the neuroendocrine system that controls responses to stress, and has an important function in the regulation of various body processes.... |
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Autocrine effects of neuromedin B stimulate the proliferation of rat primary osteoblasts.
J. Endocrinol. 217(2) , 141-50, (2013) Neuromedin B (NMB) is a mammalian bombesin-like peptide that regulates exocrine/endocrine secretion, smooth muscle contraction, body temperature, and the proliferation of some cell types. Here, we sho... |
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Effect of potential on temperature-dependent SERS spectra of neuromedin B on Cu electrode.
Phys. Chem. Chem. Phys. 15(3) , 807-15, (2013) Adsorption of decapeptide neuromedin B (NMB) on copper electrode has been investigated by in situ surface-enhanced Raman scattering (SERS) spectroelectrochemistry in the temperature interval from 12 t... |
| GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 |
| GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 ACOH 5H2O |
| NEUROMEDIN B,PORCINE |
| GNLWATGHFM-NH2 |
| Gly-L-Asn-L-Leu-L-Trp-L-Ala-L-Thr-Gly-L-His-L-Phe-L-Met-NH2 |
| H-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 |
| NEUROMEDIN B,PORCINE MAMMALIAN BOMBESIN-LI |
| neuromedin-B |
| Neuromedin B |
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