(S)-(+)-咯利普兰

• 常用名: (S)-(+)-咯利普兰
• 英文名: S-(+)-Rolipram
• CAS号: 85416-73-5
• 分子量: 275.343
• 密度: 1.2±0.1 g/cm3
• 沸点: 472.7±45.0 °C at 760 mmHg
• 分子式: C₁₆H₂₁NO₃
• 熔点: 133-136ºC
• 闪点: 239.7±28.7 °C

(S)-(+)-咯利普兰用途

(S)-(+)-Rolipram是cAMP特异的PDE4抑制剂,有抗炎活性,活性小于其R型对映体。

(S)-(+)-咯利普兰名称

• 中文名: (S)-4-[3-(环戊基氧基)-4-甲氧基苯基]-2-吡咯烷酮
• 英文名: (+)-rolipram
• 中文别名: 盐酸环胞苷 | (4S)-4-[3-(环戊基氧基)-4-甲氧基苯基]-2-吡咯烷酮 | S- (+)-咯利普兰

(S)-(+)-咯利普兰生物活性

• 描述: (S)-(+)-Rolipram是cAMP特异的PDE4抑制剂,有抗炎活性,活性小于其R型对映体。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44.

  [2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98.

  [3]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr

  [4]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.

(S)-(+)-咯利普兰物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 472.7±45.0 °C at 760 mmHg
• 熔点: 133-136ºC
• 分子式: C₁₆H₂₁NO₃
• 分子量: 275.343
• 闪点: 239.7±28.7 °C
• 精确质量: 275.152130
• PSA: 47.56000
• LogP: 1.43
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.552
• 储存条件: Store at RT

(S)-(+)-咯利普兰安全信息

• 海关编码: 2933790090

(S)-(+)-咯利普兰海关

• 海关编码: 2933790090
• 中文概述: 2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:9.0% 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

(S)-(+)-咯利普兰英文别名

• (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
• S2127_Selleck
• (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
• 1oyn
• S- (+)-Rolipram
• 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)-
• S-(+)-Rolipram
• (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• S-(+)-4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone
• (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
• (-)-rolipram
• 1xn0
• (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
• (+)-rolipram
• (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-
• 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)-
• (S)-(+)-Rolipram