水飞蓟宾A,B(混合物)

更新时间：2024-01-05 15:09:05

水飞蓟宾A,B(混合物)结构式	常用名	水飞蓟宾A,B(混合物)	英文名	Silybin
	CAS号	802918-57-6	分子量	482.43600
	密度	N/A	沸点	N/A
	分子式	C₂₅H₂₂O₁₀	熔点	152-153°C
	MSDS	中文版美版	闪点	N/A
	符号	GHS07	信号词	Warning

水飞蓟宾A,B(混合物)用途

Silybin 是一种从草蓟 (Silybum marianum) 种子中分离出来的黄素寡糖。Silybin 诱导凋亡 (apoptosis),并具有保肝,抗氧化,抗炎,抗癌活性。

中文名	水飞蓟宾
英文名	silibinin
英文别名	更多

描述	Silybin 是一种从草蓟 (Silybum marianum) 种子中分离出来的黄素寡糖。Silybin 诱导凋亡 (apoptosis),并具有保肝,抗氧化,抗炎,抗癌活性。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 癌症研究领域 >> 炎症/免疫
体外研究	水飞蓟宾(0-200mm；72小时)具有时间和剂量依赖性的生长抑制作用[1]。水飞蓟宾(68μM；72小时)诱导细胞凋亡,使G1期细胞增加约22%[1]。水飞蓟宾(68μM；72小时)诱导AKT活性抑制[1]。细胞活力测定[1]细胞系：HepG2细胞生长浓度：0-200mm孵育时间：72h结果：生长抑制呈时间和剂量依赖性,IC50为68μM。凋亡分析[1]细胞系：HepG2细胞生长浓度：68μM孵育时间：72h结果：诱导凋亡的细胞数较多细胞(60%)相比,未经处理的细胞。细胞周期分析[1]细胞系：HepG2细胞生长浓度：68μM孵育时间：72h结果：G1期细胞增加约22%,S期细胞减少47%。westernblot分析[1]细胞株：HepG2细胞生长浓度：68μM孵育时间：72h结果：诱导AKT活性抑制。
体内研究	水飞蓟宾(50100毫克/千克/天；过去4周内灌胃给药)显著降低血清和肝脏脂质积聚[2]。动物模型：非酒精性脂肪性肝病(NAFLD)雄性C57BL/6J小鼠(6-8周龄)[2]剂量：50100 mg/kg给药：灌胃给药；每日一次；最后4周结果：显著降低血清和肝脏脂质积聚。
参考文献	[1]. Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20(9):2190. [2]. Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721.

熔点	152-153°C
分子式	C₂₅H₂₂O₁₀
分子量	482.43600
精确质量	482.12100
PSA	155.14000
LogP	2.36270
储存条件	Refrigerator

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
危害码 (欧洲)	Xi
风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	26-37/39
危险品运输编码	NONH for all modes of transport
RTECS号	DJ2981770

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silibin

silybin

Silybin

Silybin A,B (mixture)