(D(CH2)51,TYR(ET)2,VAL4,ARG8)-VASOPRESSIN结构式
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常用名 | (D(CH2)51,TYR(ET)2,VAL4,ARG8)-VASOPRESSIN | 英文名 | SKF 100398 |
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| CAS号 | 77453-01-1 | 分子量 | 1136.39000 | |
| 密度 | 1.44g/cm3 | 沸点 | N/A | |
| 分子式 | C53H77N13O11S2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
用途SKF 100398 (d(CH2)5Tyr(Et)VAVP) 是一种精氨酸加压素 (AVP) 类似物,能作为外源性和内源性 AVP 抗利尿作用的特异性拮抗剂。 |
| 中文名 | (D(CH2)51,TYR(ET)2,VAL4,ARG8)-VASOPRESSIN |
|---|---|
| 英文名 | β-MERCAPTO-β,β-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2 |
| 英文别名 | 更多 |
| 描述 | SKF 100398 (d(CH2)5Tyr(Et)VAVP) 是一种精氨酸加压素 (AVP) 类似物,能作为外源性和内源性 AVP 抗利尿作用的特异性拮抗剂。 |
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| 相关类别 | |
| 体内研究 | SKF 100398是外源性和内源性AVP通水作用的特异性拮抗剂[1]。SKF 100398(8个)μg/kg；i、 消除AVP的抗利尿作用[1]。动物模型：雄性Sprague-Dawley大鼠(250-300g)[1]剂量：8μg/kg给药：静脉注射结果：完全阻断外源性AVP(4ng/kg体重)的抗利尿作用。 |
| 参考文献 |
| 密度 | 1.44g/cm3 |
|---|---|
| 分子式 | C53H77N13O11S2 |
| 分子量 | 1136.39000 |
| 精确质量 | 1135.53000 |
| PSA | 431.92000 |
| LogP | 4.60970 |
| 折射率 | 1.676 |
| 符号 |
GHS07 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H332 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
| 危害码 (欧洲) | Xn: Harmful; |
| 风险声明 (欧洲) | 20 |
| 安全声明 (欧洲) | 36 |
| 危险品运输编码 | NONH for all modes of transport |
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(D(CH2)51,TYR(E... 77453-01-1 |
| 文献：Manning, Maurice; Lammek, Bernard; Kolodziejczyk, Alexander M. Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 701 - 706 |
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Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.
Proc. Natl. Acad. Sci. U. S. A. 92(4) , 1013-7, (1995) Water excretion by the kidney is regulated by the peptide hormone vasopressin. Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed fro... |
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Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems.
Nature 337(6208) , 648-51, (1989) Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the ... |
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Pharmacological characterization of V1a vasopressin receptors in the rat cortical collecting duct.
Am. J. Physiol. 262 , F546-F553, (1992) Vasopressin receptors in distal segments of the rat nephron were identified in isolated tubules using two labeled ligands: the [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid), 2-(O-meth... |
| M.W. 1136.41 C53H77N13O11S2 |
| type 1 arginine vasopressin antagonist |
| (d(CH2)51,Tyr(Et)2,Val4,Arg8)-Vasopressin |
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